Journal of Cardiac Failure
Volume 14, Issue 1 , Pages 1-5 , February 2008

A Randomized, Controlled Trial of the Renal Effects of Ultrafiltration as Compared to Furosemide in Patients With Acute Decompensated Heart Failure

  • Hobart L. Rogers, PharmD

      Affiliations

    • University of Maryland School of Pharmacy, Baltimore, Maryland
    • ,
  • Joanne Marshall, BSN

      Affiliations

    • University of Maryland School of Medicine, Baltimore, Maryland
    • ,
  • Jeremy Bock, MD

      Affiliations

    • University of Maryland School of Medicine, Baltimore, Maryland
    • ,
  • Thomas C. Dowling, PharmD, PhD

      Affiliations

    • University of Maryland School of Pharmacy, Baltimore, Maryland
    • ,
  • Erika Feller, MD

      Affiliations

    • University of Maryland School of Medicine, Baltimore, Maryland
    • ,
  • Shawn Robinson, MD

      Affiliations

    • University of Maryland School of Medicine, Baltimore, Maryland
    • ,
  • Stephen S. Gottlieb, MD

      Affiliations

    • University of Maryland School of Medicine, Baltimore, Maryland
    • Baltimore Veterans Administration Medical Center, Baltimore, Maryland
    • Corresponding Author InformationReprint requests: Stephen Gottlieb, MD, Division of Cardiology, University of Maryland Medical Systems, 22 S. Greene St., Baltimore, MD 21201.

Received 20 June 2007 ,Revised 2 August 2007 ,Accepted 8 September 2007.

References 

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  2. Heart Failure Society of America. Executive Summary: HFSA 2006 Comprehensive Heart Failure Practice Guidelines. J Card Fail. 2006;12:10–38
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  10. Agostoni P, Marenzi G, Lauri G, Perego G, Schianni M, Sganzerla P, et al. Sustained improvement in functional capacity after removal of body fluid with isolated ultrafiltration in chronic cardiac insufficiency: failure of furosemide to provide the same result. Am J Med. 1994;96:191–199
  11. Constanzo MR, Saltzberg M, O'Sullivan J, Sobotka P. Early ultrafiltration in patients with decompensated heart failure and diuretic resistance. J Am Coll Cardiol. 2005;46:2047–2051
  12. Costanzo MR, Guglin ME, Saltzberg MT, Jessup ML, Bart BA, Teerlink JR, et al. UNLOAD Trial Investigators. Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure. J Am Coll Cardiol. 2007;49:675–683
  13. Rimondini A, Cipolla CM, Della Bella P, Grazi S, Sisillo E, Susini G, et al. Hemofiltration as short-term treatment for refractory congestive heart failure. Am J Med. 1987;83:43–48
  14. Marenzi G, Lauri G, Grazi M, Assanelli E, Campodonico J, Agostoni P. Circulatory response to fluid overload removal by extracorporeal ultrafiltration in refractory congestive heart failure. J Am Coll Cardiol. 2001;38:963–968
  15. Dowling TC, Frye RF, Zemaitis M. Simultaneous determination of p-aminohippuric acid (APH), acetyl-p-aminohippuric acid and iothalamate in human plasma and urine by high-performance liquid chromatography. J Chromatogr B Biomed Applic. 1998;716:305–313
  16. Dowling TC, Frye RF, Fraley DS, Matzke GR. Comparison of iothalamate clearance methods for measuring GFR. Pharmacotherapy. 1999;19:943–950
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  18. Weber PC, Scherer B, Larsson C. Increase of free arachidonic acid by furosemide in man as the cause of prostaglandin and renin release. Eur J Pharmacol. 1977;41:329–332
  19. Pourageaud F, Bappel-Gozalbes C, Marthan R, Freslon JL. Role of EDHF in the vasodilatory effect of loop diuretics in guinea-pig mesenteric resistance arteries. Br J Pharmacol. 2000;131:1211–1219
  20. Schnermann J, Briggs J. Restoration of tubuloglomerular feedback in volume expanded rats by angiotensin II. Am J Physiol. 1990;259:F565–F572
  21. Thomson S, Bao D, Deng A, Vallon V. Adenosine formed by 5′-nucleotidase mediates tubuloglomerular feedback. J Clin Invest. 2000;106:289–298
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  23. Ali SS, Olinger CC, Sobotka PA, Bernard S, Dahle TG, Bunte MC, et al. Enhanced sodium extraction with ultrafiltration compared with intravenous diuretics. J Card Fail. 2006;6:S114
  24. Butler J, Forman DE, Abraham WT, Gottlieb SS, Loh E, Massie BM, et al. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients. Am Heart J. 2004;147:331–338

 All decisions regarding this manuscript were made by a guest editor.This study was funded by CHF Solutions, Inc., Minneapolis, Minnesota.

PII: S1071-9164(07)01071-8

doi: 10.1016/j.cardfail.2007.09.007

Journal of Cardiac Failure
Volume 14, Issue 1 , Pages 1-5 , February 2008

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