Journal of Cardiac Failure
Volume 14, Issue 1 , Pages 61-74, February 2008

Cytokines and Myocardial Dysfunction: State of the Art

  • Ayman A. El-Menyar, MBchB, MSc, FRCP

      Affiliations

    • Corresponding Author InformationReprint requests: Ayman Ahmed ElMenyar, MBBCH, MSc, MRCP (UK), Weill Cornell Faculty of Medicine, Doha, Qatar & Department of Cardiology and Cardiovascular Surgery, Hamad General Hospital, PO Box 3050, Doha, State of Qatar.

Weill Cornell University, Faculty of Medicine, Qatar, and the Department of Cardiology and Cardiovascular Surgery/Hamad General Hospital, Doha, Qatar

Received 8 August 2007; received in revised form 7 September 2007; accepted 10 September 2007. published online 03 January 2008.

Abstract 

Background

Myocardial dysfunction has been associated with inflammation and cytokine modulation.

Objectives

The study objective was to understand the role of cytokines in the pathophysiology and management of myocardial dysfunction.

Methods

Heart failure has been revisited with revision of the pertinent published articles in the Medline, Scopus, Cochrane Database of Systematic Reviews, and EBSCO Host research.

Results

For the proinflammatory cytokines, illumination of this important point requires further diagnostic and therapeutic investigations. Data on chronic heart failure are not so reassuring; therefore, patients with advanced heart failure should not be treated with anticytokines at this time.

Conclusion

Further studies are warranted to pave the way for introducing cytokine and immunomodulation therapy at the optimal and appropriate time.

Key Words: Cytokine, heart failure, interleukin, myocardial dysfunction proinflammatory, tumor necrosis factor

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PII: S1071-9164(07)01070-6

doi:10.1016/j.cardfail.2007.09.006

Journal of Cardiac Failure
Volume 14, Issue 1 , Pages 61-74, February 2008

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