Journal of Cardiac Failure
Volume 14, Issue 1 , Pages 9-18 , February 2008

Impact of Cardiac Resynchronization Therapy on Exercise Performance, Functional Capacity, and Quality of Life in Systolic Heart Failure With QRS Prolongation: COMPANION Trial Sub-Study

  • Teresa De Marco, MD

      Affiliations

    • University of California, San Francisco Medical Center, San Francisco, CA
    • Corresponding Author InformationReprint requests: Teresa De Marco, MD, FACC, University of California, San Francisco, Division of Cardiology, 505 Parnassus Avenue, 1180-M, San Francisco, CA 94143-0124.
    • ,
  • Eugene Wolfel, MD

      Affiliations

    • University of Colorado Health Sciences Center, Denver, CO
    • ,
  • Arthur M. Feldman, MD, PhD

      Affiliations

    • Thomas Jefferson Medical College, Philadelphia, PA
    • ,
  • Brian Lowes, MD

      Affiliations

    • University of Colorado Health Sciences Center, Denver, CO
    • ,
  • Michael B. Higginbotham, MD

      Affiliations

    • Duke University, Chapel Hill, NC
    • ,
  • Jalal K. Ghali, MD

      Affiliations

    • Wayne State University School of Medicine, Detroit, MI
    • ,
  • Lynne Wagoner, MD

      Affiliations

    • University Hospital, Cincinnati, OH
    • ,
  • Philip C. Kirlin, MD

      Affiliations

    • The Care Group at Methodist Hospital, Indianapolis, IN
    • ,
  • Jerry D. Kennett, MD

      Affiliations

    • Missouri Cardiovascular Specialists, Columbia, MO
    • ,
  • Satish Goel, MD

      Affiliations

    • Baptist Medical Center, Jacksonville, FL
    • ,
  • Leslie A. Saxon, MD

      Affiliations

    • University of Southern California, Keck School of Medicine, Los Angeles, CA
    • ,
  • John P. Boehmer, MD

      Affiliations

    • Milton S. Hershey Medical Center, Penn State School of Medicine, Hershey, PA
    • ,
  • David Mann, MD

      Affiliations

    • Cardiovascular Associates, Louisville, KY
    • ,
  • Elizabeth Galle, MS

      Affiliations

    • Boston Scientific CRM, St. Paul, MN
    • ,
  • Fred Ecklund, MA

      Affiliations

    • Boston Scientific CRM, St. Paul, MN
    • ,
  • Patrick Yong, MSEE
    • ,
  • Michael R. Bristow, MD, PhD

      Affiliations

    • University of Colorado Health Sciences Center, Denver, CO
    • Boston Scientific CRM, St. Paul, MN

Received 14 November 2006 ,Revised 27 July 2007 ,Accepted 1 August 2007.

References 

  1. Cleland JG, Thackray S, Goodge L, et al. Outcome studies with device therapy in patients with heart failure. J Cardiovasc Electrophysiol. 2002;13:S73–S91
  2. Executive summary: HFSA comprehensive heart failure practice guidelines. J Cardiac Fail. 2006;12:10–38
  3. ACC/AHA guideline update for the diagnosis and management of chronic heart failure in the adult—summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to update the 2001 guidelines for the evaluation and management of heart failure). J Am Coll Cardiol. 2005;46:1116–1143
  4. Packer M, Cohn JN. Consensus recommendations for the management of chronic heart failure. Am J Cardiol. 1999;83:1A–38A
  5. Abraham WT, Fischer WG, Smith AL, et al. for the MIRACLE Study Group Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346:1845–1853
  6. Young JB, Abraham WT, Smith AL, et al. for the Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE ICD) Trial Investigators Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure. The MIRACLE ICD trial. JAMA. 2003;289:2685–2694
  7. Cleland JGF, Daubert J-C, Erdmann E, et al. for the Cardiac Resynchronization–Heart Failure (CARE-HF) Study Investigators The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005;352:1539–1549
  8. Higgins SL, Hummel JD, Niazi IK, et al. Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias. J Am Coll Cardiol. 2003;42:1454–1459
  9. Cazeau S, Leclercq C, Lavergne T, et al. for the Multisite Stimulation in Cardiomyopathies (MUSTIC) Study Investigators Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med. 2001;344:873–880
  10. Auricchio A, Stellbrink C, Sack S, et al. for the Pacing Therapies in Congestive Heart failure (PATH-CHF) Study Group Long-term clinical effect of hemodynamically optimized cardiac resynchronization therapy in patients with heart failure and ventricular conduction delay. J Am Coll Cardiol. 2002;39:2026–2033
  11. Cazeau S, Leclercq C, Lavergne T, Walker S, Varma C, Linde C, et al. Multisite stimulation in Cardiomyopathies (MUSTIC) Study Investigators Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med. 2001;344:873–880
  12. Bristow MR, Saxon LA, Boehmer J, et al. for the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004;350:2140–2150
  13. Weber KT, Kinasewitz GT, Janicki JS, Fishman AP. Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure. Circulation. 1982;65:1213–1223
  14. Lipkin D, Scriven AJ, Crake T, Poole-Wilson PA. Six minute walking test for assessing exercise capacity in chronic heart failure. BMJ. 1986;292:653–655
  15. Rector RS, Kubo SH, Cohn JN. Patients' self-assessment of their congestive heart failure. II. Content, reliability, and validity of a new measure—the Minnesota Living with Heart Failure questionnaire. Heart Fail. 1987;3:198–209
  16. Jennrich RI, Schlucter MD. Unbalanced repeated measures models with structured covariance matrices. Biometrics. 1986;42:805–820
  17. Crawford SL, Tennstedt SL, McKinlay JB. A comparison of analytic methods for non-random missingness of outcome data. J Clin Epidemiol. 1995;48:209–219
  18. SAS System 9 Doc: SAS Online Doc 9.1.3. Available from: http://support.sas.com/onlinedoc/913/docMainpage.jsp. Accessed August 17, 2007.
  19. Lavori PW, Dawson R, Shera D. A multiple imputation strategy for clinical trials with truncation of patient data. Stat Med. 1995;14:1913–1925
  20. Rubin DB. Multiple imputation for non-response in surveys. New York: John Wiley & Son, Inc; 1987;
  21. Middlekauff HR. How does cardiac resynchronization therapy improve exercise capacity in chronic heart failure?. J Cardiac Fail. 2005;11:534–541
  22. Wilson JR, Rayos G, Yeoh TK, Gothard P, Bak K. Dissociation between exertional symptoms and circulatory function in patients with heart failure. Circulation. 1995;92:47–53
  23. St. John Sutton MG, Plappert T, Abraham WT, Smith AL, Delergio DB, Leon AR, et al. Multicenter InSync Randomized Clinical Evaluation (MIRACLE) Study Group Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure. Circulation. 2003;107:1985–1990
  24. Kass DA, Chen CH, Curry C, Talbot M, Berger R, Fetics B, et al. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation. 1999;99:1567–1573

 All decisions regarding this manuscript were made by a guest editor.

 Supported by a grant from Guidant Corporation.

PII: S1071-9164(07)01024-X

doi: 10.1016/j.cardfail.2007.08.003

Journal of Cardiac Failure
Volume 14, Issue 1 , Pages 9-18 , February 2008

Article Tools

* Image Usage & Resolution