Journal of Cardiac Failure
Volume 13, Issue 9 , Pages 759-764 , November 2007

Exercise-Induced Increases in Oxidized Low-Density Lipoprotein Are Associated With Adverse Outcomes in Chronic Heart Failure

  • Ulrich P. Jorde, MD

      Affiliations

    • Division of Cardiology, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, New York
    • Corresponding Author InformationReprint requests: Ulrich P. Jorde, MD, Center for Advanced Cardiac Care, Columbia University Medical Center, 170 Ft. Washington Avenue, New York, NY 10032.
  • ,
  • Paolo C. Colombo, MD

      Affiliations

    • Division of Cardiology, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, New York
  • ,
  • Kartikya Ahuja, MD

      Affiliations

    • Leon Charney Division of Cardiology, New York University School of Medicine, New York, New York
  • ,
  • Alhakam Hudaihed, MD

      Affiliations

    • Division of Cardiology, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, New York
  • ,
  • Duygu Onat, PhD

      Affiliations

    • Division of Cardiology, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, New York
  • ,
  • Thomas Diaz, MD

      Affiliations

    • Division of Cardiology, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, New York
  • ,
  • David S. Hirsh, MD

      Affiliations

    • Leon Charney Division of Cardiology, New York University School of Medicine, New York, New York
  • ,
  • Edward A. Fisher, MD

      Affiliations

    • Leon Charney Division of Cardiology, New York University School of Medicine, New York, New York
  • ,
  • Chi-Hong Tseng, PhD

      Affiliations

    • Leon Charney Division of Cardiology, New York University School of Medicine, New York, New York
  • ,
  • Timothy J. Vittorio, MD

      Affiliations

    • Division of Cardiology, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, New York

Received 20 February 2007 ,Revised 21 May 2007 ,Accepted 18 June 2007.

References 

  1. Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation. 2003;108:1912–1916
  2. Keith M, Geranmayegan A, Sole F, Michael J, Kurian R, Robinson A, et al. Increased oxidative stress in patients with congestive heart failure. J Am Coll Cardiol. 1998;31:1352–1356
  3. Mak S, Newton GE. The oxidative stress hypothesis of congestive heart failure: radical thoughts. Chest. 2001;120:2035–2046
  4. Shishehbor MH, Aviles RJ, Brennan ML, Fu X, Goormastic M, Pearce GL, et al. Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. JAMA. 2003;289:1675–1680
  5. Sugiyama M, Ohashi M, Takase H, Sato K, Ueda R, Dohi Y. Effects of atorvastatin on inflammation and oxidative stress. Heart Vessels. 2005;20:133–136
  6. Tsutsui T, Tsutamoto T, Wada A, Maeda K, Mabuchi N, Hayashi M, et al. Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure. J Am Coll Cardiol. 2002;39:957–962
  7. George J, Wexler D, Roth A, Barak T, Sheps D, Keren G. Usefulness of anti-oxidized LDL antibody determination for assessment of clinical control in patients with heart failure. Eur J Heart Fail. 2006;8:58–62Epub 2005 Aug 1
  8. Tang WH, Brennan ML, Philip K, Tong W, Mann S, Van Lente F, et al. Plasma myeloperoxidase levels in patients with chronic heart failure. Am J Cardiol. 2006;98:796–799
  9. Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation. 2001;104:2673–2678
  10. Neuberg GW, Friedman SH, Weiss MB, Herman MV. Cardiopulmonary exercise testing. The clinical value of gas exchange data. Arch Intern Med. 1988;148:2221–2226
  11. Sugiuchi H, Irie T, Uji Y, Ueno T, Chaen T, Uekama K, et al. Homogeneous assay for measuring low-density lipoprotein cholesterol in serum with triblock copolymer and alpha-cyclodextrin sulfate. Clin Chem. 1998;44:522–531
  12. Holvoet P, Donck J, Landeloos M, Brouwers E, Luijtens K, Arnout J, et al. Correlation between oxidized low density lipoproteins and von Willebrand factor in chronic renal failure. Thromb Haemost. 1996;76:663–669
  13. Tsimikas S, Witztum JL. Measuring circulating oxidized low-density lipoprotein to evaluate coronary risk. Circulation. 2001;103:1930–1932
  14. Metso S, Loimaala A, Mercuri MF, Nenonen A, Vuori I, Oja P, et al. Circulating oxidized low-density lipoprotein and common carotid artery intima-media thickness in a random sample of middle-aged men. J Biomed Sci. 2004;11:356–361
  15. Ndrepepa G, Braun S, von Beckerath N, Mehilli J, Gorchakova O, Vogt W, et al. Oxidized low density lipoproteins, statin therapy and severity of coronary artery disease. Clin Chim Acta. 2005;360:178–186
  16. Yucel D, Aydogdu S, Cehreli S, Saydam G, Canatan H, Senes M, et al. Increased oxidative stress in dilated cardiomyopathic heart failure. Clin Chem. 1998;44:148–154
  17. Nishiyama Y, Ikeda H, Haramaki N, Yoshida N, Imaizumi T. Oxidative stress is related to exercise intolerance in patients with heart failure. Am Heart J. 1998;135:115–120
  18. Colombo PC, Banchs JE, Celaj S, Talreja A, Lachmann J, Malla S, et al. Endothelial cell activation in patients with decompensated heart failure. Circulation. 2005;111:58–62
  19. Katz SD, Hryniewicz K, Hriljac I, Balidemaj K, Dimayuga C, Hudaihed A, et al. Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure. Circulation. 2005;111:310–314
  20. Lonn E, Yusuf S, Hoogwerf B, Pogue J, Yi Q, Zinman B, et al. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care. 2002;25:1919–1927
  21. Tousoulis D, Antoniades C, Vassiliadou C, Toutouza M, Pitsavos C, Tentolouris C, et al. Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure. Eur J Heart Fail. 2005;
  22. Gomez-Cabrera MC, Borras C, Pallardo FV, Sastre J, Ji LL, Vina J. Decreasing xanthine oxidase mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J Physiol. 2005;567(Pt 1):113–120Epub 2005 Jun 2
  23. Mercken EM, Hageman GJ, Schols AM, Akkermans MA, Bast A, Wouters EF. Rehabilitation decreases exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2005;172(8):994–1001Epub 2005 Jul 22
  24. Ennezat PV, Malendowicz SL, Testa M, Colombo PC, Cohen-Solal A, Evans T, et al. Physical training in patients with chronic heart failure enhances the expression of genes encoding antioxidative enzymes. J Am Coll Cardiol. 2001;38:194–198
  25. Steffen Y, Schewe T, Sies H. Epicatechin protects endothelial cells against oxidized LDL and maintains NO synthase. Biochem Biophys Res Commun. 2005;331:1277–1283
  26. Steffen Y, Schewe T, Sies H. Myeloperoxidase-mediated LDL oxidation and endothelial cell toxicity of oxidized LDL: attenuation by (-)-epicatechin. Free Radic Res. 2006;40:1076–1085
  27. Feigenbaum MS, Welsch MA, Brechue WF, Handberg-Thurmond EM, Pollock ML, Pepine CJ. Plasma volume changes with an acute bout of high-intensity exercise in men with chronic congestive heart failure secondary to coronary artery disease. Am J Cardiol. 1998;81:509–513
  28. Skinner ER, Watt C, Maughan RJ. The acute effect of marathon running on plasma lipoproteins in female subjects. Eur J Appl Physiol Occup Physiol. 1987;56:451–456
  29. Goodyear LJ, Van Houten DR, Fronsoe MS, Rocchio ML, Dover EV, Durstine JL. Immediate and delayed effects of marathon running on lipids and lipoproteins in women. Med Sci Sports Exerc. 1990;22:588–592
  30. Paolisso G, Gambardella A, Galzerano D, D'Amore A, Rubino P, Verza M, et al. Total-body and myocardial substrate oxidation in congestive heart failure. Metabolism. 1994;43:174–179
  31. Tuunanen H, Engblom E, Naum A, Nagren K, Hesse B, Airaksinen KE, et al. Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure. Circulation. 2006;114:2130–2137
  32. Taegtmeyer H, Ballal K. No low-fat diet for the failing heart?. Circulation. 2006;114:2092–2093
  33. Cabassi A, Coghi P, Govoni P, Barouhiel E, Speroni E, Cavazzini S, et al. Sympathetic modulation by carvedilol and losartan reduces angiotensin II-mediated lipolysis in subcutaneous and visceral fat. J Clin Endocrinol Metab. 2005;90:2888–2897

PII: S1071-9164(07)00939-6

doi: 10.1016/j.cardfail.2007.06.724

Journal of Cardiac Failure
Volume 13, Issue 9 , Pages 759-764 , November 2007