Journal of Cardiac Failure
Volume 13, Issue 8 , Pages 672-679, October 2007

Prognostic Significance and Measurement of Exercise-Derived Hemodynamic Variables in Patients With Heart Failure

  • Chim C. Lang, MD

      Affiliations

    • Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, United Kingdom
    • Division of Cardiology, Columbia Presbyterian Medical Center, New York, New York
    • ,
  • Piergiuseppe Agostoni, MD, PhD

      Affiliations

    • Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universitá di Milano, Milan, Italy
    • ,
  • Donna M. Mancini, MD

      Affiliations

    • Division of Cardiology, Columbia Presbyterian Medical Center, New York, New York
    • Corresponding Author InformationReprint requests: Donna Mancini, MD, Center for Advanced Cardiac Care, Division of Cardiology, Columbia University Medical Center, Room PH 1273, 622 West 168th Street, New York, NY 10032.

Received 31 August 2006; received in revised form 10 May 2007; accepted 15 May 2007.

Abstract 

The peak VO2 is an important prognostic measurement in the evaluation of patients with heart failure and is used to monitor the progress of the condition, especially in selecting patients for cardiac transplantation. However, peak VO2 may be influenced by noncardiac factors such as age, sex, motivation, anemia, and muscle deconditioning. These confounding factors may diminish somewhat the prognostic power of peak VO2. Several groups have looked at exercise-derived variables beyond peak VO2 to assess whether a more direct assessment of cardiac function, using exercise-derived hemodynamic variables, may yield more precise prognostic information than standard cardiopulmonary-derived data. This article reviews the evidence that cardiac work related to exercise may enhance the prognostic value of peak VO2 in the evaluation of patients with heart failure and briefly discusses the available methods for measuring these parameters.

Key Words: Chronic heart failure, cardiac transplantation, exercise, cardiac output

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 Conflict of Interest Disclosures: None of the authors have a conflict of interest.

PII: S1071-9164(07)00166-2

doi:10.1016/j.cardfail.2007.05.004

Journal of Cardiac Failure
Volume 13, Issue 8 , Pages 672-679, October 2007

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