Journal of Cardiac Failure
Volume 13, Issue 5 , Pages 340-345 , June 2007

The Safety of Amiodarone in Patients With Heart Failure

  • Christian Torp-Pedersen, MD

      Affiliations

    • From the Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark
    • Corresponding Author InformationReprint requests: Prof. Christian Torp-Pedersen, Department of Cardiology, Bispebjerg University Hospital, 2400 Copenhagen NV, Denmark.
    • ,
  • Marco Metra, MD

      Affiliations

    • Cattedra di Cardiologia, Università di Brescia, Italy
    • ,
  • Philip Spark, PhD

      Affiliations

    • Nottingham Clinical Research Group (NCRG), Nottingham, UK
    • ,
  • Mary Ann Lukas, MD

      Affiliations

    • GlaxoSmikthKline, Philadelphia, Pennsylvania
    • ,
  • Christine Moullet, MD

      Affiliations

    • F. Hoffmann-La Roche, Basel, Switzerland
    • ,
  • Armin Scherhag, MD

      Affiliations

    • I Medical Clinic, University Hospital Mannheim, University of Heidelberg, Germany and F. Hoffmann-La Roche, Basel, Switzerland
    • ,
  • Michel Komajda, MD

      Affiliations

    • La Pitié-Salpétriêre Hospital, Paris, France
    • ,
  • John G.F. Cleland, MD

      Affiliations

    • Department of Cardiology, University of Hull, Kingston upon Hull, UK
    • ,
  • Willem Remme, MD

      Affiliations

    • Sticares Cardiovascular Research Foundation, Rhoon, Netherlands
    • ,
  • Andrea Di Lenarda, MD

      Affiliations

    • Department of Cardiology, Ospedale di Cattinara, Trieste, Italy
    • ,
  • Karl Swedberg, MD

      Affiliations

    • Department of Medicine, Sahlgrenska University Hospital/Östra, Göteborg, Sweden
    • ,
  • Philip A. Poole-Wilson, MD

      Affiliations

    • National Heart and Lung Institute, Imperial College London, UK
    • The COMET investigators are listed in a previous publication: Poole-Wilson PA, Swedberg K, Cleland JG, et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomized controlled trial. Lancet 2003;362:7–13.
    • ,
  • for the COMET Investigators

Received 26 October 2006 ,Revised 23 February 2007 ,Accepted 28 February 2007.

References 

  1. Fuster V, Ryden LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 guidelines for the management of patients with atrial fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace. 2006;8:651–745
  2. Doval HC, Nul DR, Perrone SV, Bortman GR, Curiel R (GESICA) fGdEdlSelIeA. Randomized trial of low dose amiodarone in severe congestive heart failure. Lancet. 1994;344:493–498
  3. Singh SN, Fletcher RD, Fisher SG, Singh BN, Lewis HD, Deedwania PC, et al. Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure. [comments] N Engl J Med. 1995;333:77–82
  4. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al. Amiodarone or an Implantable Cardioverter-Defibrillator for Congestive Heart Failure. N Engl J Med. 2005;352:225–237
  5. Poole-Wilson PA, Swedberg K, Cleland JG, Di Lenarda A, Hanrath P, Komajda M, et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet. 2003;362:7–13
  6. Poole-Wilson PA, Cleland JG, Di Lenarda A, Hanrath P, Komajda M, Metra M, et al. Rationale and design of the carvedilol or metoprolol European trial in patients with chronic heart failure: COMET. Eur J Heart Fail. 2002;4:321–329
  7. Torp-Pedersen C, Poole-Wilson P, Swedberg K, Cleland J, Di Lenarda A, Hanrath P, et al. Effects of metoprolol and carvedilol on cause-specific mortality and morbidity in patients with chronic heart failure—COMET. Am Heart J. 2005;149:370–376
  8. Julian DG, Camm AJ, Frangin G, Janse MJ, Munoz A, Schwartz PJ, et al. Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT. European Myocardial Infarct Amiodarone Trial Investigators. Lancet. 1997;349:667–674
  9. Cairns JA, Connolly SJ, Roberts R, Gent M. Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Investigators. Lancet. 1997;349:675–682
  10. Massie BM, Fisher SG, Radford M, Deedwania PC, Singh BN, Fletcher RD, et al. Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure. CHF-STAT Investigators. Circulation. 1996;93:2128–2134
  11. Macdonald PS, Keogh AM, Aboyoun C, Lund M, Amor R, McCaffrey D. Impact of concurrent amiodarone treatment on the tolerability and efficacy of carvedilol in patients with chronic heart failure. Heart. 1999;82:589–593
  12. Boutitie F, Boissel JP, Connolly SJ, Camm AJ, Cairns JA, Julian DG, et al. Amiodarone interaction with beta-blockers: analysis of the merged EMIAT (European Myocardial Infarct Amiodarone Trial) and CAMIAT (Canadian Amiodarone Myocardial Infarction Trial) databases. The EMIAT and CAMIAT Investigators. Circulation. 1999;99:2268–2275

PII: S1071-9164(07)00069-3

doi: 10.1016/j.cardfail.2007.02.009

Journal of Cardiac Failure
Volume 13, Issue 5 , Pages 340-345 , June 2007

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