Journal of Cardiac Failure
Volume 12, Issue 7 , Pages 520-526 , September 2006

Early Activation of an Altered Thyroid Hormone Profile in Asymptomatic or Mildly Symptomatic Idiopathic Left Ventricular Dysfunction

Received 6 March 2006 ,Revised 24 May 2006 ,Accepted 26 May 2006.

References 

  1. Manowitz NR, Mayor GH, Klepper MJ, DeGroot LJ. Hypothyroidism and thyroid sick syndrome in patients with moderate to severe congestive heart failure. Am J Ther. 1996;3:797–801
  2. Hamilton MA, Stevenson LW, Luu M, Walden JA. Altered thyroid hormone metabolism in advanced heart failure. J Am Coll Cardiol. 1990;16:91–95
  3. Pingitore A, Landi P, Taddei MC, Ripoli A, L'Abbate A, Iervasi G. Triiodothyronine levels for risk stratification of patients with chronic heart failure. Am J Med. 2005;118:132–136
  4. Kozdag G, Ural D, Vural A, et al. Relation between free triiodothyronine/free thyroxine ratio, echocardiographic parameters and mortality in dilated cardiomyopathy. Eur J Heart Failure. 2005;7:113–118
  5. Ascheim DD, Hryniewicz K. Thyroid hormone metabolism in patients with congestive heart failure: the low triiodothyronine state. Thyroid. 2002;12:511–515
  6. Iervasi G, Pingitore A, Landi P, et al. Low T3 syndrome: a strong prognostic predictor of death in patients with heart disease. Circulation. 2003;107:708–713
  7. Cohn JN, Levine TB, Olivari MT, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med. 1984;311:819–823
  8. Francis GS, Benedict C, Johnstone DE, et al. Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the 9. Studies of left ventricular dysfunction (SOLVD). Circulation. 1990;82:1724–1729
  9. Mann DL. Mechanism and model in heart failure. Circulation. 1999;100:999–1008
  10. Koglin J, Pehlivanli S, Schwaiblmair M, Vogeser M, Cremer P, VonScheidt W. Role of brain natriuretic peptide in risk stratification of patients with congestive heart failure. J Am Coll Cardiol. 2001;38:1934–1941
  11. Opie LH. Cellular basis for therapeutic choices in heart failure. Circulation. 2004;110:2559–2561
  12. Packer M. Neurohormonal interactions and adaptations in congestive heart failure. Circulation. 1998;77:721–730
  13. Boelen A, Platvoet-ter SM, Schiphorst MC, Wiersinga WM. Association between serum interleukin-6 and serum 3, 5, 3′-triiodothyronin in nonthyroidal illness. J Clin Endocrinol Metab. 1993;77:1695–1699
  14. Boelen A, Maas MA, Lowik CW, Platvoet-ter SM, Wiersinga WM. Induced illness in interleukin-6 (IL-6) knock-out mice: a casual role of IL-6 in the development of the low 3, 5, 3′-triiodothyronine syndrome. Endocrinology. 1996;137:5250–5254
  15. Boelen A, Kwakkel J, Platvoet-ter SM, Baur A, Kohrle J, Wiersinga WM. Contribution of interleukin-12 to the pathogenesis of non-thyroidal illness. Horm Metab Res. 2004;36:101–106
  16. Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med. 2001;344:501–509
  17. Kahaly GJ, Dillmann WH. Thyroid hormone action in the heart. Endocr Rev. 2005;6:704–728
  18. Sabatino L, Colantuoni A, Iervasi G. Is the vascular system a main target for thyroid hormones? From molecular and biochemical findings to clinical perspectives. Curr Vasc Pharmacol. 2005;3:133–145
  19. Neglia D, Michelassi C, Trivieri MG, et al. Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction. Circulation. 2002;15:186–193
  20. Emdin M, Passino C, Prontera C, et al. Cardiac natriuretic hormones, neuro-hormones, thyroid hormones and cytokines in normal subjects and patients with heart failure. Clin Chem Lab Med. 2004;42:627–636
  21. Iervasi G, Emdin M, Colzani RMP, et al. Beneficial effects of long-term triiodothyronine (T3) infusion in patients with advanced heart failure and low T3 syndrome. In:  Kimchi A editors. Heart disease: new trends in research, diagnosis and treatment. Englewood (NJ): Medimont; 2001;p. 549–553
  22. Moruzzi P, Doria E, Agostoni PG. Medium-term effectiveness of L-thyroxine treatment in idiopathic dilated cardiomyopathy. Am J Med. 1996;101:461–467
  23. Hamilton MA, Stevenson LW, Fonarow GC. Safety and hemodynamic effects of intravenous triiodothyronine in advanced congestive heart failure. Am J Cardiol. 1998;81:443–447
  24. Pingitore A, Iervasi G. Thyroid (dys)function in heart failure: is it a potential target for medical treatment?. Vascular Health Risk Manage. 2005;1:97–100
  25. Zoccali C, Tripepi G, Cutrupi S, Pizzini P, Mallamaci F. Low triiodothyronine: a new facet of inflammation in end-stage renal disease. J Am Soc Nephrol. 2005;16:2789–2795
  26. Colantuoni A, Marchiafava PL, Lapi D, Forini FS, Iervasi G. Effects of tetraiodothyronine and triiodothyronine on hamster cheek pouch microcirculation. Am J Physiol Heart Circ Physiol. 2005;288:H1931–H1936
  27. Trivieri MG, Oudit GY, Sah R, et al. Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Proc Natl Acad Sci U S A. 2006;11(103):6043–6048
  28. Khalife WI, Tang Y, Kuzman JA, et al. Treatment of sub-clinical hypothyroidism reverses ischemia and prevents myocyte loss and progressive LV dysfunction in hamsters with dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2005;289:H2409–H2415
  29. Wassen FW, Schiel AE, Kuiper GG, et al. Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure. Endocrinology. 2002;143:2812–2815
  30. Scanlan TS, Suchland KL, Hart ME, et al. 3-iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat Med. 2004;10:638–642
  31. Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ. Alternate pathways of thyroid hormone metabolism. Thyroid. 2005;15:943–958
  32. Tang YD, Kuzman JA, Said S, Anderson BE, Wang X, Gerdes AM. Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction. Circulation. 2005;112:3122–3130

PII: S1071-9164(06)00276-4

doi: 10.1016/j.cardfail.2006.05.009

Journal of Cardiac Failure
Volume 12, Issue 7 , Pages 520-526 , September 2006

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