Journal of Cardiac Failure
Volume 11, Issue 8 , Pages 602-606 , October 2005

High Prevalence of Microalbuminuria in Chronic Heart Failure Patients

  • Ruud M.A. van de Wal, MD, PharmD

      Affiliations

    • From the Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands
    • Corresponding Author InformationReprint requests: Ruud M.A. van de Wal, Department of Cardiology, St Antonius Hospital, PO Box 2500 3430 EM Nieuwegein, the Netherlands.
    • ,
  • Folkert W. Asselbergs, MD, PhD

      Affiliations

    • Department of Cardiology, University Hospital Groningen, Groningen, The Netherlands
    • ,
  • H.W. Thijs Plokker, MD, PhD

      Affiliations

    • From the Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands
    • ,
  • Tom D.J. Smilde, MD

      Affiliations

    • Department of Cardiology, University Hospital Groningen, Groningen, The Netherlands
    • ,
  • Dirk Lok, MD

      Affiliations

    • Department of Cardiology, Deventer Hospital, Groningen, The Netherlands
    • ,
  • Dirk J. van Veldhuisen, MD, PhD

      Affiliations

    • Department of Cardiology, University Hospital Groningen, Groningen, The Netherlands
    • ,
  • Wiek H. van Gilst, PhD

      Affiliations

    • Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    • ,
  • Adriaan A. Voors, MD, PhD

      Affiliations

    • Department of Cardiology, University Hospital Groningen, Groningen, The Netherlands

Received 1 December 2004 ,Revised 11 May 2005 ,Accepted 17 May 2005.

References 

  1. Hillege HL, Fidler V, Diercks GF, van Gilst WH, de Zeeuw D, van Veldhuisen DJ, et al. Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population. Circulation. 2002;106:1777–1782
  2. Gerstein HC, Mann JF, Yi Q, Zinman B, Dinneen SF, Hoogwerf B, et al. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA. 2001;286:421–426
  3. Garg AX, Kiberd BA, Clark WF, Haynes RB, Clase CM. Albuminuria and renal insufficiency prevalence guides population screening: results from the NHANES III. Kidney Int. 2002;61:2165–2175
  4. Hillege HL, Janssen WM, Bak AA, Diercks GF, Grobbee DE, Crijns HJ, et al. Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J Intern Med. 2001;249:519–526
  5. Eiskjaer H, Bagger JP, Mogensen CE, Schmitz A, Pedersen EB. Enhanced urinary excretion of albumin in congestive heart failure: effect of ACE-inhibition. Scand J Clin Lab Invest. 1992;52:193–199
  6. Berl T. Angiotensin-converting enzyme inhibitors versus AT1 receptor antagonist in cardiovascular and renal protection: the case for AT1 receptor antagonist. J Am Soc Nephrol. 2004;15(Suppl 1):S71–S76
  7. Cockroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41
  8. de Jong PE, Hillege HL, Pinto-Sietsma SJ, de Zeeuw D. Screening for microalbuminuria in the general population: a tool to detect subjects at risk for progressive renal failure in an early phase?. Nephrol Dial Transplant. 2003;18:10–13
  9. Arnold JM, Yusuf S, Young J, Mathew J, Johnstone D, Avezum A, et al. Prevention of Heart Failure in Patients in the Heart Outcomes Prevention Evaluation (HOPE) Study. Circulation. 2003;107:1284–1290
  10. de Zeeuw D, Remuzzi G, Parving HH, Keane WF, Zhang Z, Shahinfar S, et al. Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy. Circulation. 2004;110:921–927
  11. Carrie BJ, Hilberman M, Schroeder JS, Myers BD. Albuminuria and the permselective properties of the glomerulus in cardiac failure. Kidney Int. 1980;17:507–514
  12. Pinto-Sietsma SJ, Janssen WM, Hillege HL, Navis G, de Zeeuw D, de Jong PE. Urinary albumin excretion is associated with renal functional abnormalities in a nondiabetic population. J Am Soc Nephrol. 2000;11:1882–1888
  13. Giannattasio C, Achilli F, Grappiolo A, Failla M, Meles E, Gentile G, et al. Radial artery flow-mediated dilatation in heart failure patients: effects of pharmacological and nonpharmacological treatment. Hypertension. 2001;38:1451–1455
  14. Varin R, Mulder P, Tamion F, Richard V, Henry JP, Lallemand F, et al. Improvement of endothelial function by chronic angiotensin-converting enzyme inhibition in heart failure: role of nitric oxide, prostanoids, oxidant stress, and bradykinin. Circulation. 2000;102:351–356
  15. Liu JE, Robbins DC, Palmieri V, Bella JN, Roman MJ, Fabsitz R, et al. Association of albuminuria with systolic and diastolic left ventricular dysfunction in type 2 diabetes: the Strong Heart Study. J Am Coll Cardiol. 2003;41:2022–2028
  16. Devereux RB, Roman MJ, Paranicas M, Lee ET, Welty TK, Fabsitz RR, et al. A population-based assessment of left ventricular systolic dysfunction in middle-aged and older adults: the Strong Heart Study. Am Heart J. 2001;141:439–446
  17. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators. Lancet. 2000;355:253–259
  18. Parving HH, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med. 2001;345:870–878
  19. Swedberg K, Eneroth P, Kjekshus J, Wilhelmsen L. Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group. Circulation. 1990;82:1730–1736
  20. Houlihan CA, Tsalamandris C, Akdeniz A, Jerums G. Albumin to creatinine ratio: a screening test with limitations. Am J Kidney Dis. 2002;39:1183–1189

 F.W. Asselbergs is a research fellow of the Netherlands Heart Foundation (2003T010). D.J. van Veldhuisen is an established investigator of the Netherlands Heart Foundation.

PII: S1071-9164(05)00238-1

doi: 10.1016/j.cardfail.2005.05.007

Journal of Cardiac Failure
Volume 11, Issue 8 , Pages 602-606 , October 2005

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